Project 1 Research Team

Edward Fisher, MD, MPH, PhD (Co-Investigator)

Leon H. Charney Professor of Cardiovascular Medicine
Professor, Departments of Medicine, Pediatrics, and Cell Biology
Director, Center for the Prevention of Cardiovascular Disease
Director, Marc and Ruti Bell Program in Vascular Biology
New York University Langone Medical Center

Dr. Edward Fisher is the Leon Charney Professor of Cardiovascular Medicine at the New York University (NYU) School of Medicine. At NYU, he is also the Director of the Center for the Prevention of Cardiovascular Disease and Director of the Marc and Ruti Bell Program in Vascular Biology. He is a graduate of the NYU School of Medicine and received his clinical training at Duke and Harvard. He also holds a PhD from MIT in biochemistry and nutrition and was a post-doctoral fellow at the NIH in molecular genetics.

Dr. Fisher’s research program includes investigations of the cell biology of the very low density lipoproteins (the precursors of LDL), the regression of atherosclerosis, including its imaging, and the development of nanoparticles to target therapies directly to atherosclerotic plaques and other sites of inflammation. He is also an active practitioner in preventive cardiology with a particular interest in lipid risk factors.

Kathryn Moore, PhD (Co-Investigator)

Jean and David Blechman Professor of Cardiology
Professor, Department of Cell Biology
New York University Langone Medical Center

Dr. Kathryn Moore is an Associate Professor at New York University School of Medicine in the Marc and Ruti Bell Vascular Biology and Disease Program. Dr. Moore is an established researcher in the field of inflammatory mechanisms of atherosclerosis, with research interests that include: (1) molecular mechanisms of sterile inflammation in atherosclerosis and Alzheimer’s disease, (2) regulation of cholesterol metabolism, and (3) role of positive and negative guidance cues in leukocyte trafficking. Using a variety of biochemical, genetic, cell and molecular biology techniques, Dr. Moore’s laboratory has uncovered novel roles for scavenger receptor, nuclear hormone receptor and Toll-like receptor pathways in the host response to infection and modified-self ligands that accumulate in disease states. Her research has improved our understanding of how immune cells respond to atherogenic lipids and b-amyloid, and contribute to the pathology that underlies sterile inflammatory diseases such as atherosclerosis and Alzheimer’s disease. Dr. Moore’s research aims to further the understanding and prevention of chronic inflammatory disorders through interdisciplinary study of the molecular mechanisms regulating the initiation, promotion and resolution of macrophage inflammatory responses.