We have three main Projects complemented by an Administrative/Statistical Core and Imaging Core. We will tackle the Program Project’s central hypothesis in three Specific Aims from the vantage points of biology, technology, and medicine.

In Aim 1 (Biology) – Project 1, we will investigate how stress controls macrophage dynamics in mouse models of atherosclerosis.

In Aim 2 (Technology) – Project 2, we will develop and translate non-invasive imaging approaches and nanotechnologies that monitor macrophage dynamics in atherosclerosis during stress.

In Aim 3 (Medicine) – Project 3, we will elucidate the mechanism by which PTSD leads to atherosclerosis.