“Stress and Atherosclerotic Plaque Macrophages – A Systems Biology Approach” also known as STRIVE, is a five-year Research Program funded by the National Heart, Lung, and Blood Institute of the National Institutes of Health (NHLBI/NIH) that aims to uncover the mechanisms by which stress contributes to cardiovascular risk.  The program aims to improve our understanding of how the effect of stress on the brain can directly impact the immune system and cardiovascular disease, and to provide a scientific platform for clinicians and researchers to integrate this knowledge into patient care.

The program consists of three distinct projects. The first will use mouse models to explore how the brain reacts to stress and affects the immune system to increase cardiovascular disease risk. The second study will translate discoveries from the first to develop non-invasive imaging methodologies, such as combined MRI and PET scans, in order to study these same processes in larger mammals and humans. The third study will then use these imaging technologies to examine the link between increased emotional stress and increased cardiovascular risk in human subjects diagnosed with post-traumatic stress disorder (PTSD).

STRIVE will take place at three institutions: Icahn School of Medicine at Mount Sinai (ISMMS), New York University Langone Medical Center (NYU), and Massachusetts General Hospital (MGH).



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